DICOVAL ER 500
24-Hour Stability for Neurological and Emotional Balance
Overview
DICOVAL ER 500 is an advanced Extended-Release (ER) formulation of Divalproex Sodium, a gold-standard therapy in both neurology and psychiatry. Utilizing a sophisticated controlled-release polymer matrix, DICOVAL ER 500 provides a steady, therapeutic plasma concentration over a full 24-hour cycle. This modern delivery system significantly reduces the "peak-to-trough" fluctuations seen with immediate-release versions, leading to superior patient tolerability and consistent symptomatic control.
Key Composition
Each film-coated extended-release tablet contains:
- Divalproex Sodium (equivalent to Valproic Acid): 500 mg
Mechanism of Action
DICOVAL ER 500 stabilizes neuronal activity through a multi-targeted pharmacological approach:
- GABAergic Modulation: It increases the concentration and activity of Gamma-Aminobutyric Acid (GABA)—the brain's primary inhibitory neurotransmitter—by stimulating its synthesis and inhibiting its degradation.
- Sodium Channel Blockade: It suppresses high-frequency repetitive neuronal firing by blocking voltage-sensitive sodium channels, preventing the initiation and spread of abnormal electrical impulses.
- T-Type Calcium Channel Inhibition: It modulates calcium influx, which is particularly effective in managing absence seizures and maintaining mood stability.
The DICOVAL ER 500 Advantage
- Once-Daily Convenience: The extended-release profile allows for once-a-day dosing, greatly improving long-term patient compliance compared to multiple daily doses.
- Consistent Neuro-Protection: By maintaining stable blood levels, DICOVAL ER 500 helps prevent "breakthrough" seizures and sudden mood shifts.
- Enhanced Tolerability: Lower peak plasma levels reduce common dose-related side effects, such as gastrointestinal distress, tremors, and sedation.
- Optimized Compliance: The simplified regimen is ideal for long-term maintenance therapy in chronic neurological conditions.
Dosage & Administration
As prescribed by a physician. Tablets must be swallowed whole and should not be crushed or chewed to preserve the extended-release properties of the polymer matrix.